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Aromatase inhibitors anastrozole, exemestane and letrozole

If you no longer need to take Aromasin and have leftover medication, it’s important to dispose of it safely. This helps prevent others, including children and pets, from taking the drug by accident. If you’re taking a medication that contains estrogen, tell your doctor before using Aromasin.

• All the women had breast cancer progression (spreading or worsening of the cancer) even after treatment with tamoxifen or chemotherapy.
• This side effect can be serious enough to cause some women to stop taking the drugs.
• But in fact, it’s best not to use Arimidex or any AI during PCT (instead, SERMs and HCG should be taken to stimulate testosterone).
• Additionally, a cross-sectional study on postmenopausal women found a link between rising body mass index and circulating estrogens (E1 and E2) 32.
• In a study of females taking Arimidex as a first treatment for advanced breast cancer, it took an average of 11.1 months for the cancer to worsen.
• Tumors that are hormone insensitive do not have hormone receptors and do not respond to hormone therapy.

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It is thought that the activation of AT2 receptors will counteract the stimulation of AT1 receptors 93. In estrogen-treated ovariectomized mice, the expression of AT2 receptors in the kidneys is increased, resulting in a reduced AT1/AT2 receptor ratio that favors vasodilation 81,94. This may contribute to the preventive effects of estrogen on the progression of renal disease. The RAAS is composed of a series of enzyme–catalyzed interactions between its components, which regulate cardiovascular and renal function. The main precursor of the RAAS (angiotensinogen) is produced by the liver 80.

After the menopause, the ovaries no longer produce oestrogen, but https://thuongxuanonline.net/norditropin-flexpro-15-iu-novo-nordisk-4/ some oestrogen is still made in body fat. This process involves an enzyme (a type of protein) called aromatase. Stopping the ovaries producing oestrogen using surgery, drugs or radiotherapy.

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They are used to treat some types of breast cancer in women who have gone through menopause. There are 3 aromatase inhibitors available in Aotearoa New Zealand – anastrozole, exemestane and letrozole. Findings from randomized controlled trials have shown the aromatase inhibitors exemestane and anastrozole may lower the risk of developing breast cancer in postmenopausal women at high risk . Among postmenopausal women with hormone receptor-positive breast cancer, aromatase inhibitors (alone or after tamoxifen) offer the same or slightly greater benefit compared to tamoxifen alone 100, . Aromatase inhibitors only work in post-menopausal women, but tamoxifen and raloxifene work in both pre- and post-menopausal women. Clinical trials have shown that aromatase inhibitors are about 30% more effective in preventing breast cancer recurrence than tamoxifen or raloxifene.

Aromatase inhibitor therapy has side effects that may affect your quality of life. If you’re taking an aromatase inhibitor, ask your healthcare provider about ways to reduce side effects so you can continue treatment that helps you live free of breast cancer. But high estrogen levels may increase your risk of developing ER-positive breast cancer. Aromatase inhibitors block the enzyme aromatase, which turns other hormones into estrogen.

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